Mjolnir: Deformable Image Registration using Feature Diffusion

Image registration is the process of aligning separate images into a common reference frame so that they can be compared visually or statistically. In order for this alignment to be accurate and correct it is important to identify the correct anatomical correspondences between different subjects. We propose a new approach for a feature-based, inter-subject deformable image registration method using a novel displacement field interpolation. Among the top deformable registration algorithms in the literature today is the work of Shen et al. called HAMMER. This is a feature-based, hierarchical registration algorithm, which introduces the novel idea of fusing feature and intensity matching. The algorithm presented in this paper is an implementation of that method, where significant improvements of some important aspects have been made. A new approach to the algorithm will be introduced as well as clarification of some key features of the work of Shen et al. which have not been elaborated in previous publications. The new algorithm, which is referred to as Mjolnir (Thor’s hammer), was validated on both synthesized and real T1 weighted MR brain images. The results were compared with results generated by HAMMER and show significant improvements in accuracy with reduction in computation time.